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Causes of Vision Loss

Age-related Macular Degeneration

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Crude prevalence of vision loss due to age-related macular degeneration, Global, South Asia, North Africa and Middle East, 2020

(all ages, males & females)

Source: Data from VLEG/GBD 2020 model, accessed via the IAPB Vision Atlas

Age-related Macular Degeneration: Global summary

The age-standardised prevalence of blindness due to age-related macular degeneration (AMD) declined by almost 30% from 1990 to 2020, which was likely associated with the widespread clinical introduction of anti-VEGF (vascular endothelial growth factor) therapy for exudative AMD.

Since most patients with AMD show the currently untreatable non-exudative form that can progress to atrophy of the foveal centre (geographic atrophy), the development of treatments and prophylactic measures specifically against non-exudative AMD are required.

The annual incidence (new cases each year) of early and late AMD is 1.59% and 0.19% respectively. Since 2000, the incidence (new cases each year) of early AMD has slightly decreased, however the incidence of late AMD has remained unchanged (Zhou et al., 2021).

It’s important to also note that for every person that experiences vision impairment and blindness from AMD, there are many more living with early stage AMD who need comprehensive and integrated people centred eye care services to prevent vision loss.


Related pages on the Vision Atlas